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D27.505.519.625.375.425.400.500
1.A class of non-sedating drugs that bind to but do not activate histamine receptors (INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.;Active enantiomers and selective derivatives of second generation H1 antagonists.
D27.505.519.625.375.425.400
1.Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
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D27.505.519.625.375.425.400
D27.505.696.577.375.425.400, Antagonists, Histamine H1 (MeSH), Antagonists, Histamine H1 Receptor (MeSH), Antihistamines (MeSH), Antihistamines, Classical (MeSH), Antihistaminics, Classical (MeSH), Antihistaminics, H1 (MeSH), Blockaders, Histamine H1 Receptor (MeSH), First Generation H1 Antagonists (MeSH), H1 Receptor Blockaders (MeSH), Histamine H1 Antagonists (MeSH), Histamine H1 Blockers (MeSH), Histamine H1 Receptor Antagonists (MeSH), Histamine H1 Receptor Blockaders (MeSH), Receptor Blockaders, H1 (MeSH)
D27.505.519.625.375.425.400.500
D27.505.696.577.375.425.400.500, H1 Antihistamines, Non-Sedating (MeSH), Histamine H1 Antagonists, Non-Sedating (MeSH), Second Generation Antihistamines (MeSH), Second Generation H1 Antagonists (MeSH), Third Generation H1 Antagonists (MeSH)
D27.505.519.625.375.425.400
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